NEWS ABOUT THE CURE

Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma

In a study funded by The Cure Starts Now and the DIPG/DMG Collaborative, Dr. Dun discusses the initial effects of differing formulations of ONC201. Background Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood brainstem tumor for which radiation is the only treatment. Case studies report a clinical response to ONC201 for patients with H3K27M-mutant gliomas. Oncoceutics (ONC201) is only available in the United States and Japan; however, in Germany, DIPG patients can be prescribed and…

The H2A.Z-nuclesome code in mammals: emerging functions

A recent publication in Trends in Genomics highlighted Dr. Valdes-Mora's investigation into the functions and role of histone variations in cancers. This helps to define relevant targets not only in DIPG but also other cancers for the next group of trials. This investigation was funded by the DIPG/DMG Collaborative. Highlights The histone variant H2A.Z has been involved in many diverse and contrasting functions. H2A.Z complex biology, including different post-translational modificatio…

Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies

Dr. Dun’s latest research helps to outline key attributes between DIPG and DMGs and how we might best find complementary strategies to attack DMG to improve prognoses.  This, when combined with further genetic analysis, will lead to improved outcomes for children fighting these brain tumors. Abstract Diffuse midline glioma (DMG) is a deadly pediatric and adolescent central nervous system (CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a median overall…

Dosing Optimization of CED Drug Delivery for DIPG

A recent publication in the Journal of Neurosurgery highlighted Dr. Souweidane's efforts to leverage software in order to better predict CED drug delivery in DIPG patients. This may improve researchers' ability to optimize dosing for drugs delivered by CED, such as chemotherapy. CED administration in DIPG patients is largely thanks to research funding by The Cure Starts Now. Abstract With increasing use of convection-enhanced delivery (CED) of drugs, the need for software that can predict infu…

Groundbreaking Brain Cancer Trial Funded by Local Charities Demonstrates 2/3 Survival of Mice and Heads to Human Trials

Every year around 200-400 children die from the incurable brain tumor, Diffuse Intrinsic Pontine Glioma (DIPG) in the US and Australia. The average age of diagnosis for DIPG is just seven years old. There are no effective treatments, and average survival is from 12-18 months. A paper published in the prestigious journal, Nature Communications, reveals a revolutionary drug combination that – in animal studies and in world first 3D models of the tumor – is “spectacularly effective in eradicating…

Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG

In 2019 Dr. Maria Tsoli and Dr. David Ziegler of Children's Cancer Institute proposed developing new epigenetic combination treatments against DIPG. This project was approved for funding by the DIPG/DMG Collaborative and The Cure Starts Now and here are the results: Abstract Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumor for which new treatments are needed. CBL0137 is an anti-cancer compound developed from quinacrine that targets facilitates chroma…

Australian Researchers Find New Way to Target Deadly Childhood Cancer With CBL0137

The following work was supported by grants from The Cure Starts Now and the DIPG/DMG Collaborative. Research by Australian scientists could pave the way to a new treatment for a currently incurable brain cancer in children called Diffuse Intrinsic Pontine Glioma, or DIPG. Affecting about 150-300 children in US each year, DIPG is a devastating disease with a median survival range of 8-11 months, according to DIPG.org. The research, led by scientists at Children’s Cancer Institute and published…

The Do's and Don'ts of Helping a Friend Whose Child is Battling Cancer

A cancer diagnosis is life-altering but when the diagnosis is for your child, life is thrown off its axis and becomes complete chaos. For parents whose child is undergoing treatment, the road is exhausting and never-ending, leaving them with little time for anything other than taking care of their child. There are many things people can do and should not do when supporting friends who are dealing with a childhood cancer diagnosis. We have compiled a list of Do’s and Don’ts to help you navigate…

Breakthrough International Cancer Trial Halts Tumor Growth

The Cure Starts Now Foundation funds novel trial that halts tumor growth in 2/3 of study CINCINNATI | February 18, 2021 – The Cure Starts Now announced that the Polyamine Pathway Metabolism as a Novel Therapeutic Option for Diffuse Intrinsic Pontine Glioma (DIPG) grant, funded in partnership with the DIPG/DMG Collaborative, has resulted in the identification of a potentially revolutionary new drug treatment for brain cancer. In pre-clinical mouse model testing, researchers found the promising…

Researchers Identify/Advance Potential Revolutionary New Drug Treatment for DIPG / DMG As Part of a Collaborative Foundational Partnership

Every year around 200-400 children die from the incurable brain tumor, Diffuse Intrinsic Pontine Glioma (DIPG) in the US and Australia. The average age of diagnosis for DIPG is just seven years. There are no effective treatments, and average survival is from 12-18 months. A paper published yesterday in the prestigious journal, Nature Communications, reveals a potential revolutionary drug combination that – in animal studies and in world first 3D models of the tumor – is “spectacularly effective…